| Centre | 95 | Hanover College | 0 | September 27 | Danville |
| Centre | 12 | Indiana University | 3 | October 4 | Bloomington |
| *Centre | - | Maryville College | - | October 4 | Danville |
| Centre | 57 | Xavier University | 0 | October 18 | Danville |
| Centre | 69 | Transylvania University | 0 | October 25 | Lexington |
| Centre | 49 | University of Virginia | 7 | November 1 | Charlottesville |
| Centre | 14 | West Virginia University | 6 | November 8 | Charleston |
| Centre | 56 | University of Kentucky | 0 | November 15 | Danville |
| Centre | 56 | DePauw University | 0 | November 22 | Louisville |
| Centre | 77 | Georgetown College | 7 | November 27 | Georgetown |
| Centre | 66 | Morris-Harvey College | 0 | October 2 | Danville |
| Centre | 120 | Howard College | 0 | October 9 | Danville |
| Centre | 55 | Transylvania University | 0 | October 16 | Danville |
| Centre | 14 | Harvard University | 31 | October 23 | Cambridge |
| Centre | 0 | Georgia Tech University | 24 | October 30 | Atlanta |
| Centre | 34 | DePauw University | 0 | November 6 | Indianapolis |
| Centre | 49 | University of Kentucky | 0 | November 13 | Lexington |
| Centre | 28 | Virginia Tech University | 0 | November 20 | Louisville |
| Centre | 103 | Georgetown College | 0 | November 25 | Danville |
| Centre | 63 | Texas Christian University | 7 | January 1, 1921 | Fort Worth Classic |
| Centre | 14 | Clemson University | 0 | October 1 | Danville |
| Centre | 14 | Virginia Tech University | 0 | October 8 | Danville |
| Centre | 28 | Xavier University | 6 | October 15 | Cincinnati |
| Centre | 98 | Transylvania University | 0 | October 22 | Lexington |
| Centre | 6 | Harvard University | 0 | October 29 | Cambridge |
| Centre | 55 | University of Kentucky | 0 | November 5 | Danville |
| Centre | 21 | Auburn University | 0 | November 12 | Birmingham |
| Centre | 25 | Washington & Lee University | 0 | November 19 | Louisville |
| Centre | 21 | Tulane University | 0 | November 24 | New Orleans |
| Centre | 38 | University of Arizona | 0 | December 26 | San Diego Christmas Classic |
| Centre | 14 | Texas A&M University | 22 | January 2, 1922 | Dallas Dixie Classic |
| Centre | 72 | Carson-Newman College | 0 | September 23 | Danville |
| Centre | 21 | Clemson University | 0 | September 30 | Clemson |
| Centre | 55 | University of Mississippi | 0 | October 7 | Danville |
| Centre | 10 | Virginia Tech University | 6 | October 14 | Richmond, Va. |
| Centre | 10 | Harvard University | 24 | October 21 | Cambridge |
| Centre | 32 | University of Louisville | 7 | October 28 | Danville |
| Centre | 27 | University of Kentucky | 3 | November 4 | Lexington |
| Centre | 27 | Washington & Lee University | 6 | November 11 | Louisville |
| Centre | 0 | Auburn University | 6 | November 18 | Birmingham |
| Centre | 42 | University of South Carolina | 0 | November 30 | Danville |
| Centre | 13 | Carson-Newman College | 0 | October 6 | Danville |
| Centre | 28 | Clemson University | 7 | October 13 | Danville |
| Centre | 29 | Oglethorpe University | 0 | October 20 | Danville |
| Centre | 0 | University of Pennsylvania | 23 | October 27 | Philadelphia |
| Centre | 10 | University of Kentucky | 0 | November 3 | Danville |
| Centre | 20 | University of the South | 6 | November 10 | Memphis |
| Centre | 17 | Auburn University | 0 | November 17 | Birmingham |
| Centre | 56 | DePauw University | 0 | November 22 | Louisville |
| Centre | 19 | Washington & Lee University | 0 | November 24 | Louisville |
| Centre | 3 | University of Georgia | 3 | December 1 | Athens |
| Centre | 0 | Valparaiso Universitye | 0 | October 4 | Danville |
| Centre | 43 | Transylvania University | 0 | October 18 | Danville |
| Centre | 6 | West Virginia University | 13 | October 25 | New York |
| Centre | 7 | University of Kentucky | 0 | November 1 | Lexington |
| Centre | 32 | University of Tennessee | 0 | November 8 | Knoxville |
| Centre | 17 | University of Alabama | 0 | November 15 | Birmingham |
| Centre | 14 | University of Georgia | 7 | November 29 | Danville |
| Centre | 10 | Kentucky Wesleyan College | 7 | October 3 | Danville |
| Centre | 0 | Oglethorpe University | 20 | October 10 | Atlanta |
| Centre | 13 | Michigan State University | 15 | October 17 | Lansing |
| Centre | 13 | Western Kentucky University | 0 | October 24 | Bowling Green |
| Centre | 0 | University of Kentucky | 16 | October 31 | Danville |
| Centre | 0 | University of Tennessee | 12 | November 7 | Danville |
| Centre | 3 | Georgetown University | 41 | November 14 | Washington, D.C. |
| Centre | 34 | Georgetown College | 6 | November 20 | Danville |
| Centre | 0 | University of South Carolina | 20 | November 28 | Columbia |